
Nano
and Green Technology 2009 Conference and Symposium
COLLOIDS AND SURFACES, NANOPARTICLES,
AND GREEN TECHNOLOGY 2009 - Emphasizing Emerging Science and Technologies, Materials, Applications,
Commercialization and Business Opportunities
Javits Convention Center, New York, NY
November 17-19, 2009
Organized by
INNOVATIVE
RESEARCH AND PRODUCTS (iRAP), INC.
In Conjunction and Partnership
With
CHEM SHOW 2009
(www.chemshow.com)
Institutional Sponsors
Clarkson
University – NY State Supported Center for Advanced Materials Processing (CAMP)
Columbia University - NSF Center for Particulate And
Surfactant Systems
NanoBusiness Alliance
National Institute of Standards and Technology (NIST) – US Measurement
Systems
University of Florida - NSF Center
for Particulate and Surfactant Systems
Corporate Sponsors


Nanotechnology is already
transforming our lives with new technologies and products. As nanotechnology
tools and devices are developed, nanoparticles and nano-engineered materials and
systems will play increasingly important roles in a number of industrial
sectors such as: energy, biotechnology, electronics and information technology,
healthcare and medicine, and industrial products. New “green” technologies
under development from fuel cells to catalysts for biofuels depend on
nanoengineering.
The conference will focus on the
use and synthesis of nanoengineered materials with an emphasis on biological
applications including pharmaceuticals and devices. Cutting edge research from
some of the world's leading colloid and nano scientists, technologists and
business leaders will be presented in: colloids and surfaces, nanoparticles,
and other industrial and green technologies. The program will provide attendees
an unmatched look at the state-of-the-art in these emerging technologies and
their path to the market place.
This
unique meeting will bridge the gap between science, technology and
commercialization and attract an international group of participants that
represent the research, business, and investment communities.
PROGRAM
Tuesday,
November 17, 2009
9 a.m. to 12.30 p.m.
-Workshop I - NANO 101 –Nanoparticle Measurements and Standards
Instructors: Dr. Debra
Kaiser, Chief, Ceramics Division,
Materials and Engineering Laboratory, Dr. Robert F. Cook, Deputy Chief, Ceramics Division, Materials
and Engineering Laboratory, and Ms. Clare M. Allocca, Chief, US Measurement System Office, National Institute of Standards and
Technology (NIST). Gaithersburg, Maryland
This
workshop will address the essential role of measurement tools—standardized
methods, reference materials and data, and instrumentation—in the development
of nanomaterials for biological applications and
“green” technologies. The focus will be on physico-chemical
properties of nanoparticles, which must quantified in order to understand the benefits and potential
hazards of nanoparticles to human and environmental health.
Specific examples to be covered include measurements of nanoparticle
size and size distribution by various methods, and measurements of forces
between nanoparticles by scanning probe microscopy
methods. Efforts to catalog measurement needs and relevant tools will also be
addressed.
1.30
p.m. to 5 p.m. – Workshop II - NANO 102 – COLLOIDS
AND SURFACES, NANOPARTICLE SYNTHESIS AND PROCESSING
The workshop will start with an
overview of colloids and how they effect nanoparticle synthesis and processing. Synthesis and
processing issues of nanomaterials including
characterization, handling, agglomeration, and surface functionalization
will be highlighted. Safe handling and utilization of nanostructured
materials will also be reviewed. An attempt will be made to present selected
case studies to illustrate the applications and health & safety related
issues of engineered nanoparticulate materials.
Instructors: Prof. P.
Somasundaran, LaVon Duddleson
Krumb Professor of Mineral Engineering and Director, NSF Center for
Particulate and Surfactant Systems, Columbia University, New York City, NY; Prof.
Brij Moudgil, Distinguished
Professor and Alumni Professor of Materials Science and Engineering, and
Director of Particle Engineering Research Center, University of Florida,
Gainesville, FL
Wednesday, November 18, 2009
9.00
a.m. Conference Commences
Inaugural Conference
Session
Introduction – “Faces and Places”
Dr.
Thomas Abraham,
Program Chairman and President, iRAP, Inc.
(Stamford, CT, USA)
9.30
a.m. – 10.55 p.m.
Session
I – Nanotechnology and Nanomaterials – Emerging
Applications, Market Trends and Economic Impact
Session Chair and Moderator – Vincent Caprio, Vice
President and Events Director, NanoBusiness Alliance,
Shelton, CT
Dr. Waguih Ishak, Division VP, Science and
Technology and Director, Corning West Technology Center, Palo Alto, CA, “The Digital
Society of the 21st Century” - The Power of Photonics,
Electronic, MEMS, and Biology and Their Impact on Connecting People to the
Digital World”
·
Mega Trends
·
Problems that Matter to the
Society: Good Health, Good Communications, Good Entertainment. How can we
prolong people’s (healthy) life and improve the way they communicate with each
other?
·
The Convergence of Computers,
Communications, and Consumer Electronics
·
The Convergence of
Nanotechnology, Biotechnology, Information Technology and Cognitive Sciences
·
The Role of Innovation and
R&D over the Next Decades
Dr.
Samuel Brauer,
Principal, NanoTech Plus, LLC, Stamford, CT, “Soft
Nanotechnologies - Types and Products, Materials, Industry and Market Trends”
·
Materials
- Polymers, nanosomes, and biological compounds
·
Products
using soft nanotechnology
·
Major
markets for soft nanotechnology: cosmetics and pharmaceuticals
·
Major
Players
·
Industry
trends: past, present and future.
Alton
Parrish,
Senior Market Analyst, Innovative Research and Products, Durham, NC, “Emerging
Markets for Nanotechnology and Hard Nanomaterials”
·
Nanomaterial
Types and Applications
·
Nanotechnology Market Segments
·
Energy-related – Battery and Fuel Cells, Solar
·
Electronics, Photonics and Magnetics
·
Nano-enabled
Packaging for Foods and Beverages
10.55
–11.15 a.m. Networking Break
11.15
a.m. – 12.30 p.m.
Session
II – Emerging Developments in Colloid Science and Surface Modification
Technologies Benefiting Nanotechnology Applications
Session
Chair and Moderator – Dr. Charles Brumlik, JD, Principal,
Nanobiz, LLC., Branchburg,
NJ
Prof.
P. Somasundaran,
LaVon
Duddleson Krumb Professor
of Mineral Engineering
and Director, NSF Center for Particulate and Surfactant Systems, Columbia
University, New York City, NY, “Understanding and Tuning the Nanobiointerface for Emerging Applications”
·
Functionalization for
efficient extraction and delivery
·
Nanoparticle
design for tissue engineering
·
Modification of colloids (liposomes, nanoparticles) in food
and consumer products
·
Nanotoxicity and
its mitigation
·
Characterization of Nanopartcle surfaces for efficient utilization
Dr.
David Reisner,
Founder, Inframat Corp., Farmington, CT
Dr.
Robert F. Cook
(and Frank W. DelRio,
and Tae Joon Cho), Deputy Chief, Ceramics
Division, Materials Science and Engineering
Laboratory, National Institute of Standards and Technology (NIST),
Gaithersburg, MD, “Molecular Modification of Gold Nanoparticle Surfaces for Biomedical Applications”
·
Overview of gold nanoparticles and their
enabling aspects for biomedical applications
·
Molecular modifications of gold surfaces and nanoparticles
·
Attachment of poly (ethylene glycol) (PEG) molecules to both flat
and nanoparticle gold surfaces
·
Comparison of measurements using scanning probe microscopy (SPM)
and dynamic light scattering (DLS)
·
Attachment of “Newkome” dendrimers to gold nanoparticles
and stability of dendron modified particles
·
Stability analyses using SPM, DLS, optical absorption
spectroscopy, and X-ray photoelectron spectroscopy measurements
·
Applications of PEG- and dendron-modified
gold nanoparticles
12.55
– 2.00 p.m. Lunch Break
2.00
p.m. – 3.15 p.m.
Session
III – Nanomaterials for Nanotechnology and Green
Technology Applications
Session
Chair and Moderator – Dr. Dana Durham, Associate, Nanobiz, LLC., Pittstown, NJ
Dr.
George John,
Associate Professor of Chemistry, The City College of the City University of
New York (CUNY), New York, NY, “Green Nanotechnology: Soft NanoMaterials from Crops”
·
The self-assembly of low molecular weight building
blocks into nanoscale
·
The building blocks currently used in supramolecular chemistry
·
Chemicals and intermediates from renewable
resources to generate soft materials Generating soft materials from agri-sources - simple organic transformations and by enzyme
catalysis
·
Hydrogels as delivery vehicles.
·
Developed building blocks-to-assembled materials
from crops
Dr. Shlomo Magdassi , Michael Grouchko and
Alex Kamyshny, Casali Institute of Applied Chemistry, The
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel
“Low Cost Metallic Nanoparticles
and Inkjet Printing of
Conductive Patterns”
·
Synthesis of low cost copper nano
particles
·
Coating of copper nanoparticles
with silver
·
Formation of inkjet inks
·
High conductive printed pattern for electric devices
Dr.
Ganesh Skandan, President
and CEO, NEI Corporation, Somerset, NJ, “Nanotechnology Implications for
Improving Air Quality and Wastewater Remediation”
·
Removal of mercury from contaminated waters
·
Removal of mercury from flue gas from power plants
·
Intersection of Nanotechnology and the need for
Cleaner Air and Water
·
New treatment media for contaminated water
·
New sorbent for mercury removal from flue gas
·
Test data
3.15p.m.
– 3.30 p.m. Networking Break
3.30
p.m. – 4.45 p.m.
Session
IV – The Intersection of Nanotechnology and Biology
Session
Chair and Moderator – Jim Hurd, Director, NanoScience Exchange, San Francisco, CA
Prof. Brij Moudgil, Distinguished
Professor and Alumni Professor of Materials Science and Engineering, and
Director of Particle Engineering Research Center, University of Florida,
Gainesville, FL
Dr.
Anil Diwan,
President and Chairman, NanoViricides, Inc., West
haven, CT, "Nanoviricides - Novel Antiviral Agents Against HIV,
Influenza, and Many Other Diseases"
- What is a nanoviricide : "Find-Encapsulate-Destroy"
antiviral strategy
- FluCide(tm)
- Pan-Influenza nanoviricide against pandemic,
epidemic influenzas, bird flu, high path viruses
- HivCide(tm)
- Anti-HIV nanoviricide was superior to oral
HAART cocktail therapy in animal models
- Broad-spectrum nanoviricides - A low cost approach against Neglected
Tropical Diseases
Dr.
Anthony P. Green, Vice President, Technology Communications,
Life Sciences Group and Ben Franklin Director, The Nanotechnology Institute,
Ben Franklin Technology Partners, Philadelphia, PA, "NextGen Therapies and
Diagnostics: Nanoprobes, Nanosensors,
Nanoparticles and Nanotextiles”
·
Nanotechnology is moving from
“disruptive technology” to a “means to an end”
·
Nanotechnology applications in all
areas of life sciences:
o
Nanoprobes for intracellular investigation
o
Nanosensors for diagnostics
o
Nanoparticles for drug delivery
o
Nanotextiles for tissue engineering
·
Barriers to commercialization
4.45
p.m. – 4.50 p.m.
Concluding Remarks
and Announcements
Thursday, November 19, 2009
9.00
a.m. Conference Commences
9.00
–10.50 a.m.
Session V – Emerging Laboratory Technologies Related to
Colloids, Nanoparticles, Nano-Engineered
Materials and Green Technologies Potential for Commercialization
Session
Chair and Moderator – Dr. Philip H. Lippel, Senior Policy
Analyst, World Technology Evaluation Center, Inc., Maryland
Formation of Organic Nanoparticles
from Microemulsions for Pharmaceutical Applications, Dr. S. Magdassi and K. Margulis-Goshen, Casali Institute for Applied Chemistry, The Hebrew
University of Jerusalem, Jerusalem, Israel
Reduction in particle size of organic molecules leads to enhanced
dissolution and improved bioavailability. The main objective of our research is
to develop a new method for preparation of water-insoluble organic nanoparticles, in a form of re-dispersible powder. The
method is based on converting nanodroplets into nanoparticles of water insoluble materials, by evaporation
of all volatile solvents from an oil-in-water microemulsion,
containing a dissolved drug in the oil nanodroplets.
At the first stage, a water-immiscible drug is dissolved in a suitable
volatile organic solvent, and an oil-in-water microemulsion
is spontaneously formed by mixing it with water and proper surfactants and
co-solvents. The resulting microemulsion is a
thermodynamically stable liquid, in which the size of the oil droplets is
usually below 30 nm ,is formed without any special equipment. At the second
stage the microemulsion is directly converted into
easily dispersible powder by Spray Drying or Lyophilization,
which are common in the pharmaceutical industry.
A Proof of concept was achieved for several hydrophobic molecules, and
the process can be tailored to a variety of water insoluble drugs.For
example, powders composed of nanoparticles of propylparaben (antibacterial agent) Simvastatin
(antihyperlipidemic drug) were obtained. The
particles were either amorphous or crystalline, at the size range of 10-50 nm,
and easily dispersed in water to yield almost transparent solutions.
The simplicity and low cost of the process
make very attractive for potential use in the pharmaceutical industry.
Facile
Production of Multi-functional Nanoparticles for Drug
Delivery, Imaging, and Targeting,
Dr. Robert K. Prud’homme,
Chemical Engineering Dept., Princeton University, Princeton, NJ
Nanoparticle
formulations of hydrophobic drugs present unique opportunities for treatment of
solid tumor cancers, for delivery of drugs by aerosol administration, and as a
route to novel vaccine adjuvants. The common
requirements of these applications are precise control of particle size and
surface functionality. For cancer therapy particles in the size range of
100-200 nm passively pass through defects in the vasculature in tumors and
deposit by “enhanced permeation retention”. In addition to delivery, the
ability to monitor the fate of the nanoparticles is
also of important since anti-cancer agents are invariably toxic to healthy
tissue. Our process --Flash NanoPrecipitation – a
controlled precipitation process that produces stable nanoparticles
at high concentrations using amphiphilic diblock copolymers to direct self-assembly enables the
production of composite nanoparticles that enable
simultaneous imaging and delivery. Uniform particles with tunable sizes from
50-500 nm can be prepared in an economical and scalable manner. The key to the
process is the control of time scales for micromixing,
polymer self-assembly, and particle nucleation and growth. The PEG protective
layer creates long-circulating particles and the inclusion of PEG chains with
terminal ligands allows drug targeting. The
incorporation of gold nanoparticles, magnetic nanoparticles, or fluorophores
into the composite particle enables imaging by x-ray, MRI, or confocal microscopy, respectively. The incorporation of up
converting phosphor crystals into the composite nanoparticles
enables a highly efficient form of photodynamic therapy.
In
addition to hydrophobic compounds, peptide drugs can also be incorporated into
block copolymer protected nanoparticles.
Magnetic Nanophosphors
for MRI Contrast Enhancement and Fluorescent Labeling, Dr. Rameshwar Bhargava, Adosh
Mehta, Aleksey Ekimov,
Mahantesh Navati and Manu
Bhat, Nanocrystals Technology, Briarcliff Manor, NY
Magnetic nanoparticles are considered
an ideal agent for a wide range of applications such as contrast enhancement in
magnetic resonance imaging (MRI), targeted drug delivery, drug localization by
magnetic field etc. Materials engineering of nanoparticles
with multifunctional features that combine magnetism, fluorescence, and surface
functionalization is emerging as a major field in
diagnosis and therapy. We have synthesized magnetic nanophosphors
(MNPs), characterized their magnetic and luminescent properties, and used them
as contrast enhancing agents in the study of MRI of cancerous tumor in mice.
Significant enhancement in contrast is observed suggesting that an early
detection of cancerous-tumor is now feasible using MNPs. This breakthrough of
MNPs is expected to impact the targeted drug delivery platform for therapeutic
applications. The role of MNPs in the near future could be extended as a
magnetic carrier for targeted drug delivery. This would open the door for
reducing the dosage and efficacy in therapeutics. Several applications of this
breakthrough in nano-biotechnology will be discussed.
Silica nanoparticles Containing Aqueous
Oxidising and Antimicrobial Products, Dr.
Jaime
Rocha Gomes* and Frederico Maia** (*University of Minho, Department of Textile
Engineering, Guimarães, Portugal, **Ecoticket.Ecological Applications of Nanoparticles,
4710 Braga, Portugal)
Silica nanoparticles
are known by their innocuous effect and their biocompatibility. We present nanoparticles of silica, produced through a modified Stöber method, whereby hydrophilic water soluble products
can be immobilized.
We have synthesized nanoparticles of silica with hydrogen peroxide, peracetic acid, amines, dyes and coated particles with
silver from silver salts. These nanoparticles were
prepared by sol-gel, using an inorganic precursor of silica, and characterized
by SEM, EDS and TEM. The evaluation of the peroxide immobilized was also made
by redox titration.
The produced nanoparticles
were applied to textiles substrates and show good affinity to the natural
fibers and good wash fastness. Companies
that will be interested in this technology are detergent and stain remover
manufacturers, toothpaste
manufacturers and chemical suppliers to textiles companies.
Production of Biotechnological Lipid A-phosphate
Analogues with Antagonistic Effects in Chronic Inflammation and Allergies, Dr. H. H. Paradies@ and K.
Zimmermann§ (@Institut Charles Gerhardt de
Montpellier, ICGM, Montpellier cedex 5, France, §The Symbio Herborn Group Inc.,
Institute for Microecology, Herborn,
Germany)
A process is
disclosed for the production and therapeutic application of non-endotoxin biological materials isolated and cultured from
selected individual strains form patients, which have been afflicted with acute
or chronic infections, and can be found in fess, sputum, urine, or specific
areas of infection. The isolated and selected e.g. Gram-negative enterobacteriaceae (E. coli) are freed from enterotoxins, adhesions, and entero-hemolysines,
or eae gene
sequences, EHEC, EPEC, or molecules associated with endotoxicity
(EP 1 341 546, 2002, PCT; WO 02/28424 A2, 2002; US 09/971,557 pending). It also
possesses beneficial effects in clinical therapy against chronic inflammatory
diseases e.g. radiation damages in tumor therapy by improving the cellular immune
system, and decreasing resistance to antibiotics. It has been demonstrated that
the growth of enteric bacteria can be affected by acute or chronic diseases: (i) bacterial and viral infections in response to foreign
and resistant invaders; (ii) environmental conditions; (iii) reactions to food
(Salmonella); (iv)
rheumatism and allergic reactions to mites, pollens and animal hair.
This congenial system is built from unique chemical entities and assembles into
a number of distinct superstructures.
10.50
–11.10 a.m. Networking Break
11.10 a.m.–1.22 p.m.
Session VI – Emerging Laboratory Technologies Related to
Colloids, Nanoparticles, Nano-Engineered
Materials and Green Technologies Potential for Commercialization
Economical
Green Synthesis of Nanoporous Silica, Enabling
Material to Clean Environment, Dr. I. Sokolov, Department
of Physics, Department of Chemical and Biomolecular
Science, Nanoengineering and Biotechnology
Laboratories Center (NABLAB), Center for Advanced Materials Processing,
Center for the Environment, Clarkson University, Potsdam, NY
We
describe a novel material, nanoporous silica, which
can be used for cleaning various contaminations and pollutants. One gram of
this material has more surface area than an entire football field. Thus, it can
adsorb a substantial amount of various compounds. Different nanoporous
silica materials have been known for decades. Here we describe a novel
economical green-chemistry synthesis of the nanoporous
silica, which makes the suggested cleaning economically meaningful.
Green
Mineral Beneficiation Technology – Development of Environmentally Benign Bioreagents and Bioprocessing for
Mineral Beneficiation,
Dr.
K. A. Natarajan, Department of Materials Engineering, Indian Institute of Science, Bangalore, India
Environmentally benign and cost
effective biotechnological processes to beneficiate difficult and complex ores
such as hematite-alumina-silica, low grade bauxites and multimineral
sulfides have been developed based on microbially-induced
flotation and flocculation.
Mineral-specific bioreagents such as bioproteins and exopolysaccharides
were biochemically synthesized through growth of bacteria such as Paenibacillus polymyxa, Sulfate Reducing Bacteria, Bacillus subtilis
and yeasts in the presence of various minerals.
Utility of such as bioreagents in the
separation of alumina from hematite, silica from bauxite, iron ores and
limestone, sphalerite from galena as well as arsenopyrite from pyrite and chalcopyrite is
demonstrated. The
laboratory-demonstrated biobeneficiation processes
pave the way for development of green mineral beneficiation technologies which
are cost effective, energy-efficient and environmentally benign.
Carboranethiol Isomers Providing Molecular Protection of Silver Surfaces -
Potential for Nano-enabled Sensors, Dr.
Tomás Base, Jonathan Bould, Michael G.S. Londesborough, Academy of Sciences of the Czech Republic, Institute of Inorganic
Chemistry, Husinec-Rez, Czech Republic
We have shown recently that carboranethiol
species, functionalized inorganic clusters with rigid icosahedral
geometry, can be immobilized on gold surfaces. These species exhibit
particularly high stability towards heating, X-ray radiation, and chemical
substitution, and these features make them good candidates for the molecular
protection of silver surfaces against corrosion by hydrogen sulfide. The
ability of these species to block the corrosion by H2S in
accelerated tarnishing tests, and a comparison with various organic thiols will be presented. Aside to the remarkable capacity
for the protection of silver surfaces, we have recently investigated that
several metallaborane clusters can selectively and
reversibly uptake and release small molecules of gases such as O2,
CO, SO2, CO2 and others, and can potentially be used as
sensors.
Food
and Cosmetic Thickeners from Sugar-based NanoGels: A Biorefinery Approach, Swapnil Rohidas Jadhav
and Dr. George John, Department
of Chemistry, The City College of New York, and The Graduate School and
University Center of The City University of New
York, New York, NY
Utilizing biorefinery concept for converting crop-based resources to
functional materials is a cynosure of new manufacturing paradigm. The present
study focus of developing sugar-based low molecular weight gels (NanoGels) by biocatalysis
exemplifies the above approach. The underexplored sugar alcohols (e.g. mannitol and sorbitol) were
quantitatively converted to amphiphiles by one step
enzyme-mediated regioselective transesterification
reaction and with minimal purification protocol. The resulting amphiphiles were studied for their self-assembling behavior
in organic liquids. Intriguingly the short chain amphiphiles
{(CH2)4-8} exhibited an unprecedented capability to gel
nearly all kinds of oils (including vegetable oils). The efficiency of the
short chain sugar amphiphiles as an alternative
structuring agents for vegetable oils compared to existing oil structuring
agents was studied. In addition, effect of chiral and
structural variations in sugar amphiphiles on
microstructure formation (responsible for immobilization of organic liquid) was
also investigated. Since the developed amphiphiles
being short chain molecules eliminates increment of hyperchloesteromic
long chain fatty acid to the oil during structuring. Thus, the sugar-based amphiphiles and the assembled NanoGels
are potential healthy oil thickening agents and may find potential applications
in food and cosmetic industry.
Simple Preparation Methods of ZnO of Various Sizes and Morphologies, Zorica Crnjak Orel1, Marko Bitenc1, Yuri M. Strzhemechny2
(1National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana,
Slovenia; 2Texas Christian University, Fort Worth, Texas, USA)
ZnO
as a powder or film was prepared from non-hazardous “green” initial chemicals,
based on zinc salts and urea, by solvothermal homogenous
precipitation at low reaction temperature (<
363 °K) in water/polyol based mixture. The main advantages are
cost-effective preparation by using simple lab technique
(open reactor with constant stirring) with scale-up possibilities, fast ZnO particle growth (up to few hours) and a good control of particles sizes and
morphologies, which influence the material properties. Possible applications of the ZnO
particles prepared by our methods are in the fields of solar cells, UV
absorbers, UV lasers and other light emitting devices, catalysts, etc.
Regarding
various reaction conditions the ZnO particles could
be formed in hexagonal rod-like
and microspherical porous particles, where the length
of rod-like particles could be tuned between nano
(below 100 nm) and micro scale (up to 8
mm). The specific surface area
of microspheres is over 50 m2/g.
The nano rod-like particles have strong green
luminescence emission at ~570 nm (2.17 eV) while the
bigger rod-like particles have beside green emission also strong UV emission at ~ 390 nm (3.18 eV).
1.22
–1.27 p.m.
Concluding
Remarks
**
ABSTRACTS INVITED
Abstracts
are invited for the sessions on November 19th where presentations
will be on new laboratory findings, technologies or products which look
promising for commercialization. Send an abstract to nanotech2009@innoresearch.net.
Each selected abstract will be allotted 22 minutes for presentation to a larger
audience of technologists, business persons and investors.
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